小鼠抗ANKRD53单克隆抗体

Background:

Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD53 (ankyrin repeat domain 53) is a 530 amino acid protein that contains three ANK repeats. Conserved in chimpanzee, dog, cow, mouse and zebrafish, ANKRD53 is encoded by a gene that maps to human chromosome 2p13.3. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. Chromosome 2 contains a probable vestigial second centromere, as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes.

Applications:

WB, IF, FC

Name of antibody:

ANKRD53

Immunogen:

Fusion protein of human ANKRD53

Full name:

ankyrin repeat domain 53 (ANKRD53), transcript variant 2

Synonyms:

FLJ12056; FLJ36160

SwissProt:

Q8N9V6

WB Predicted band size:

60 kDa

WB Positive control:

HepG2, Hela, SVT2 cell lysates

WB Recommended dilution:

200-1000