兔抗CELSR1多克隆抗体

Background:

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.

Applications:

ELISA, IHC

Name of antibody:

CELSR1

Immunogen:

Synthetic peptide of human CELSR1

Full name:

cadherin EGF LAG seven-pass G-type receptor 1

Synonyms:

ME2; FMI2; CDHF9; HFMI2; ADGRC1

SwissProt:

Q9NYQ6

ELISA Recommended dilution:

500-1000

IHC positive control:

Human liver cancer and human colorectal cancer

IHC Recommend dilution:

25-100