兔抗DUSP4多克隆抗体

Background:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

Applications:

ELISA, WB, IHC

Name of antibody:

DUSP4

Immunogen:

Fusion protein of human DUSP4

Full name:

dual specificity phosphatase 4

Synonyms:

TYP; HVH2; MKP2; MKP-2

SwissProt:

Q13115

IHC positive control:

Human gastric cancer and human liver cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

43 kDa

WB Positive control:

LO2 cells

WB Recommended dilution:

200-1000