兔抗COMT多克隆抗体

Background:

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Applications:

ELISA, WB, IHC

Name of antibody:

COMT

Immunogen:

Fusion protein of human COMT

Full name:

catechol-O-methyltransferase

Synonyms:

HEL-S-98n

SwissProt:

P21964

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human ovarian cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

30 kDa

WB Positive control:

Hela cell lysate

WB Recommended dilution:

500-2000