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Background: |
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. |
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Applications: |
WB, IHC |
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Name of antibody: |
RRM2 |
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Immunogen: |
Fusion protein of human RRM2 |
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Full name: |
ribonucleotide reductase regulatory subunit M2 |
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Synonyms: |
R2; RR2; RR2M |
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SwissProt: |
P31350 |
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IHC positive control: |
Human kidney tissue and Human lung cancer; Human ovarian cancer and Human endometrial cancer |
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IHC Recommend dilution: |
50-150 |
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WB Predicted band size: |
45 KD |
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WB Positive control: |
HepG2, Hela, K562 and Jurkat cell lysates |
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WB Recommended dilution: |
200-1000 |
