兔抗DSP多克隆抗体

Background:

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.

Applications:

ELISA, IHC

Name of antibody:

DSP

Immunogen:

Synthetic peptide of human DSP

Full name:

desmoplakin

Synonyms：

DP; DPI; DPII

SwissProt:

P15924

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human breast cancer and Human brain

IHC Recommend dilution:

25-100