兔抗ABCB11多克隆抗体

Background:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Applications:

ELISA, IHC

Name of antibody:

ABCB11

Immunogen:

Synthetic peptide of human ABCB11

Full name:

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Synonyms：

BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2

SwissProt:

O95342

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human ovarian cancer and Human lung cancer

IHC Recommend dilution:

15-50