兔抗IL21R多克隆抗体

Background:

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Applications:

ELISA, IHC

Name of antibody:

IL21R

Immunogen:

Fusion protein of human IL21R

Full name:

interleukin 21 receptorp

Synonyms：

NILR; CD360

SwissProt:

Q9HBE5

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human lung cancer

IHC Recommend dilution:

25-100