兔抗ACY1多克隆抗体

Background:

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

Applications:

ELISA, WB, IHC

Name of antibody:

ACY1

Immunogen:

Fusion protein of human ACY1

Full name:

aminoacylase 1

Synonyms:

ACY-1; ACY1D

SwissProt:

Q03154

IHC positive control:

Human gastric cancer and human colon cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

46 kDa

WB Positive control:

Mouse kidney and human normal kidney tissue, K562 cells

WB Recommended dilution:

200-1000