小鼠抗MIEN1单克隆抗体

Background:

C35, also known as XTP4 (HBV X-transactivated gene 4) and protein C17orf37, is a 115 amino acid cytoplasmic protein that is a member of the SelWTH protein family. SelWTH proteins contain a thioredoxin-like fold and a conserved CxxC or CxxU motif, suggesting that they may play functional role in redox reactions. Although found at trace levels in normal breast ductal epithelium and testis, expression of C35 is robust in infiltrating ductal carcinomas of the breast, lobular carcinoma, as well as distant metastases of breast cancer such as liver, lung and skin. The prevalence and abundance of C35 overexpression in tumors suggest that it may be an appropriate bio-marker for diagnosis and a potential target for therapeutic intervention.

Applications:

WB, IHC, FC

Name of antibody:

MIEN1

Immunogen:

Fusion protein of human MIEN1

Full name:

migration and invasion enhancer 1 (MIEN1)

Synonyms:

C17orf37; C35; ORB3; RDX12; XTP4

SwissProt:

Q9BRT3

IHC positive control:

adenocarcinoma of human ovary tissue and human liver tissue; human kidney tissue and carcinoma of human prostate tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

12 kDa

WB Positive control:

Hela, SVT2, COS7, Jurkat, MDCK, PC12 cell lysates

WB Recommended dilution:

500-2000