兔抗BRCA1多克隆抗体

Background:

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Applications:

ELISA, IHC

Name of antibody:

BRCA1

Immunogen:

Fusion protein of human BRCA1

Full name:

breast cancer 1, early onset

Synonyms：

IRIS; PSCP; BRCAI; BRCC1; PNCA4; RNF53; BROVCA1; PPP1R53

SwissProt:

P38398

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human liver cancer and human cervical cancer

IHC Recommend dilution:

50-200