小鼠抗LZIC单克隆抗体

Background:

LZIC (leucine zipper and CTNNBIP1 domain containing) is a 190 amino acid protein that belongs to the CTNNBIP1 family. Ubiquitously expressed, LZIC is found at highest levels in kidney and is upregulated in a few gastric carcinomas. The gene encoding LZIC maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Applications:

WB, IHC, IF

Name of antibody:

LZIC

Immunogen:

Fusion protein of human LZIC

Full name:

leucine zipper and CTNNBIP1 domain containing (LZIC)

Synonyms:

MGC15436

SwissProt:

Q8WZA0

IHC positive control:

adenocarcinoma of human breast tissue and carcinoma of human liver tissue; carcinoma of human prostate tissue and carcinoma of human bladder tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

21 kDa

WB Positive control:

HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates

WB Recommended dilution:

500-2000