小鼠抗HDAC6单克隆抗体

Background:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.

Applications:

WB

Name of antibody:

HDAC6

Immunogen:

Fusion protein of human HDAC6

Full name:

histone deacetylase 6

Synonyms:

HD6; JM21; CPBHM; PPP1R90

SwissProt:

Q9UBN7

WB Predicted band size:

131 kDa

WB Positive control:

T47D cell, Jurkat cell, CHO-K1 cell and CHO-K1 transfected by HDAC6-fragment EGFP fusion protein cell lysates

WB Recommended dilution:

1000-5000