小鼠抗IFITM2单克隆抗体

Background:

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.

Applications:

WB, IHC

Name of antibody:

IFITM2

Immunogen:

Fusion protein of human IFITM2

Full name:

interferon induced transmembrane protein 2

Synonyms:

1-8D; DSPA2c

SwissProt:

Q01629

IHC positive control:

Human appendix tissue and Human liver tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

15 KD

WB Positive control:

HepG2, NCI-H460 cell lysates

WB Recommended dilution:

500-2000