小鼠抗FCMR单克隆抗体

Background:

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Applications:

IHC

Name of antibody:

FCMR

Immunogen:

Fusion protein of human FCMR

Full name:

Fc fragment of IgM receptor (FCMR), transcript variant 1

Synonyms:

TOSO; FAIM3

SwissProt:

O60667

IHC positive control:

carcinoma of human thyroid tissue

IHC Recommend dilution:

30-150