小鼠抗HSPB1单克隆抗体

Background:

This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.

Applications:

WB, IHC

Name of antibody:

HSPB1

Immunogen:

Fusion protein of human HSPB1

Full name:

heat shock protein family B (small) member 1

Synonyms:

CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; HEL-S-102

SwissProt:

P04792

IHC positive control:

Human tonsil and Human liver cancer; Human prostate cancer and Human gastric cancer

IHC Recommend dilution:

100-500

WB Predicted band size:

23 kDa

WB Positive control:

Lovo, Hela, HepG2 cell lysates

WB Recommended dilution:

5000-20000