兔抗CASP5多克隆抗体

Background:

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.

Applications:

ELISA, IHC

Name of antibody:

CASP5

Immunogen:

Fusion protein of human CASP5

Full name:

caspase 5, apoptosis-related cysteine peptidase

Synonyms：

ICH-3; ICEREL-III; ICE(rel)III

SwissProt:

P51878

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human thyroid cancer

IHC Recommend dilution:

25-100