小鼠抗HDAC8单克隆抗体

Background:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

WB

Name of antibody:

HDAC8

Immunogen:

Fusion protein of human HDAC8

Full name:

histone deacetylase 8

Synonyms:

HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1

SwissProt:

Q9BY41

WB Predicted band size:

42 KD

WB Positive control:

Hela, Molt4, K562, NIH/3T3, 293T and Jurkat cell lysates

WB Recommended dilution:

500-2000