兔抗DUSP27多克隆抗体

Background:

Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members, including MAPK/ERK, SAPK/JNK and p38. DUSP27 (dual specificity phosphatase 27), also known as FMDSP or DUPD1 (dual specificity phosphatase and pro isomerase domain containing 1), is a 220 amino acid cytoplasmic protein that belongs to the protein-tyrosine phosphatase family. Expressed in skeletal muscle, liver and adipose tissue, DUSP27 may play a role in energy metabolism. The gene encoding DUSP27 is referred to as DUPD1 and maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.

Applications:

ELISA, IHC

Name of antibody:

DUSP27

Immunogen:

Synthetic peptide of human DUSP27

Full name:

dual specificity phosphatase 27 (putative)

SwissProt:

Q5VZP5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer;Human thyroid cancer

IHC Recommend dilution:

50-300