小鼠抗FZD7单克隆抗体

Background:

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

Applications:

ELISA, WB

Name of antibody:

FZD7

Immunogen:

Fusion protein of human FZD7

Full name:

frizzled class receptor 7

Synonyms:

FzE3

SwissProt:

O75084

WB Predicted band size:

64 kDa

WB Positive control:

HepG2 whole cell lysate

WB Recommended dilution:

500-2000