兔抗KCNQ1多克隆抗体

Background:

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

KCNQ1

Immunogen:

Fusion protein of human KCNQ1

Full name:

potassium voltage-gated channel, KQT-like subfamily, member 1

Synonyms：

LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1

SwissProt:

P51787

ELISA Recommended dilution:

1000-2000

WB Predicted band size:

75 kDa

WB Positive control:

HT-29 cells, mouse kidney and heart tissue

WB Recommended dilution:

200-1000