小鼠抗CDKN2B单克隆抗体

Background:

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq].

Applications:

WB, IHC, FC

Name of antibody:

CDKN2B

Immunogen:

Fusion protein of human CDKN2B

Full name:

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1

Synonyms:

CDK4I; INK4B; MTS2; P15; p15INK4b; TP15

SwissProt:

P42772

IHC positive control:

human pancreas tissue and carcinoma of human thyroid tissue; adenocarcinoma of human endometrium tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

15 kDa

WB Positive control:

HepG2, Hela, Jurkat, MDCK, MCF-7 cell lysates

WB Recommended dilution:

500-2000