兔抗APLP2(Phospho-Tyr755)多克隆抗体

Background:

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Applications:

IHC

Name of antibody:

APLP2(Phospho-Tyr755)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 755 (P-T-Y(p)-K-Y) derived from Human APLP2.

Full name:

amyloid beta (A4) precursor-like protein 2

Synonyms：

APPH; APPL2; CDEBP; APLP-2

SwissProt:

Q06481

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100