兔抗CEP57多克隆抗体

Background:

This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Applications:

ELISA, WB, IHC

Name of antibody:

CEP57

Immunogen:

Full length fusion protein

Full name:

centrosomal protein 57

Synonyms:

MVA2; PIG8; TSP57

SwissProt:

Q86XR8

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and Human tonsil

IHC Recommend dilution:

25-100

WB Predicted band size:

57 kDa

WB Positive control:

Hela cell lysate

WB Recommended dilution:

500-2000