兔抗CNOT10多克隆抗体

Background:

CNOT10 is a subunit of the CCR4-NOT complex which consists of at least five other CNOT subunit proteins and TAB182. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription, as well as in mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are uniquely involved in influencing nuclear hormone receptor activities. In effect, this complex has an important role as a transcription regulator and repressor of nuclear receptor signaling that is relevant to the molecular pathways involved in cancer. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome.

Applications:

ELISA, IHC

Name of antibody:

CNOT10

Immunogen:

Fusion protein of human CNOT10

Full name:

CCR4-NOT transcription complex subunit 10

SwissProt:

Q9H9A5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human prostate cancer

IHC Recommend dilution:

20-100