兔抗CDK3多克隆抗体

Background:

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Applications:

ELISA, IHC

Name of antibody:

CDK3

Immunogen:

Synthetic peptide of human CDK3

Full name:

cyclin-dependent kinase 3

SwissProt:

Q00526

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human lung cancer

IHC Recommend dilution:

25-100