兔抗ZBTB10多克隆抗体

Background:

RINZF, also known as ZBTB10 (zinc finger and BTB domain containing protein 10), is a 847 amino acid protein that contains one BTB/POZ domain and two C2H2-type zinc fingers. Localized to the nucleus, RINZF is believed to play a role in transcriptional regulation. Specifically, RINZF is capable of binding to the CACC element of the Gastrin promoter. In this regard, RINZF competes with Sp1 for CACC binding and interferes with Sp1 transactivation, thereby regulating Gastrin gene expression. The rat RINZF protein shares 98% homology with the human RINZF protein, suggesting that RINZF is a conserved protein. Due to alternative splicing events, two RINZF isoforms exist. In addition, RINZF may be phosphorylated by ATR or ATM upon DNA damage.

Applications:

ELISA, WB, IHC

Name of antibody:

ZBTB10

Immunogen:

Synthetic peptide of human ZBTB10

Full name:

zinc finger and BTB domain containing 10

Synonyms:

RINZF

SwissProt:

Q96DT7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer and human tonsil

IHC Recommend dilution:

50-300

WB Predicted band size:

95 kDa

WB Positive control:

Jurkat cell lysate

WB Recommended dilution:

500-2000