兔抗XPC多克隆抗体

Background:

The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

XPC

Immunogen:

Synthetic peptide of human XPC

Full name:

XPC complex subunit, DNA damage recognition and repair factor

Synonyms:

XP3; RAD4; XPCC; p125

SwissProt:

Q01831

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain

IHC Recommend dilution:

30-150