兔抗CBX5(Phospho-Ser92)多克隆抗体

Background:

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Applications:

IHC

Name of antibody:

CBX5(Phospho-Ser92)

Immunogen:

Peptide sequence around phosphorylation site of Serine 92(R-S-S(p)-N-F) derived from Human HP1α .

Full name:

chromobox homolog 5

Synonyms：

HP1; HP1A; HEL25

SwissProt:

P45973

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100