兔抗BAG3多克隆抗体

Background:

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Applications:

ELISA, WB, IHC

Name of antibody:

BAG3

Immunogen:

Fusion protein of human BAG3

Full name:

BCL2 associated athanogene 3

Synonyms:

BIS; MFM6; BAG-3; CAIR-1

SwissProt:

O95817

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer and Human colorectal cancer

IHC Recommend dilution:

40-200

WB Predicted band size:

62 kDa

WB Positive control:

Mouse heart tissue lysate

WB Recommended dilution:

500-2000