兔抗ATF6B多克隆抗体

Background:

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

ATF6B

Immunogen:

Fusion protein of human ATF6B

Full name:

activating transcription factor 6 beta

Synonyms:

G13; CREBL1; CREB-RP

SwissProt:

Q99941

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and human gastric cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

77 kDa

WB Positive control:

Jurkat and Hela cell lysates

WB Recommended dilution:

200-1000