兔抗STAT5B多克隆抗体

Background:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Applications:

ELISA, IHC

Name of antibody:

STAT5B

Immunogen:

Fusion protein of human STAT5B

Full name:

Signal transducer and activator of transcription 5B

Synonyms：

STAT5

SwissProt:

P51692

ELISA Recommended dilution:

500-10000

IHC positive control:

Human lymphoma and human breast cancer

IHC Recommend dilution:

10-50