兔抗SLC12A1多克隆抗体

Background:

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.

Applications:

ELISA, WB, IHC

Name of antibody:

SLC12A1

Immunogen:

Fusion protein of human SLC12A1

Full name:

Solute carrier family 12 (sodium/potassium/chloride transporters), member 1

Synonyms：

BSC1; NKCC2

SwissProt:

Q13621

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human colon cancer and Human brain

IHC Recommend dilution:

25-100

WB Predicted band size:

121 kDa

WB Positive control:

Human fetal kidney tissue

WB Recommended dilution:

200-1000