兔抗EDEM1多克隆抗体

Background:

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Applications:

ELISA, IHC

Name of antibody:

EDEM1

Immunogen:

Synthetic peptide of human EDEM1

Full name:

ER degradation enhancing alpha-mannosidase like protein 1

Synonyms:

EDEM

SwissProt:

Q92611

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer;Human gastric cancer

IHC Recommend dilution:

10-50