兔抗GRB2多克隆抗体

IHC Recommend dilution:

25-100

IHC positive control:

Human ovarian cancer and human thyroid cancer

ELISA Recommended dilution:

2000-5000

SwissProt:

P62993

Synonyms：

ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2

Full name:

growth factor receptor-bound protein 2

Immunogen:

Full length fusion protein

Name of antibody:

GRB2

Applications:

ELISA, IHC

Background:

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.