兔抗PTK2B (Phospho-Tyr402)多克隆抗体

Background:

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

Applications:

WB, IHC, IF

Name of antibody:

PTK2B (Phospho-Tyr402)

Immunogen:

Synthetic peptide of human PTK2B (Phospho-Tyr402)

Full name:

protein tyrosine kinase 2 beta (Phospho-Tyr402)

Synonyms：

PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK

SwissProt:

Q14289

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

116 kDa

WB Positive control:

293 cells treated with Serum

WB Recommended dilution:

500-1000

IF Positive control:

Hela cells

IF Recommended dilution

100-200