兔抗PPP4R2多克隆抗体

Background:

Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.

Applications:

WB

Name of antibody:

PPP4R2

Immunogen:

Synthesized peptide derived from internal of human PP4R2.

Full name:

protein phosphatase 4, regulatory subunit 2

Synonyms：

PP4R2

SwissProt:

Q9NY27

WB Predicted band size:

47 kDa

WB Positive control:

K562 cells and COS7 cells lysates

WB Recommended dilution:

500-3000