兔抗ITGA4多克隆抗体

Background:

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

ITGA4

Immunogen:

Fusion protein of human ITGA4

Full name:

integrin subunit alpha 4

Synonyms:

IA4; CD49D

SwissProt:

P13612

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human tonsil

IHC Recommend dilution:

20-100