兔抗GLI2多克隆抗体

Background:

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

Applications:

ELISA, IHC

Name of antibody:

GLI2

Immunogen:

Synthetic peptide of human GLI2

Full name:

GLI family zinc finger 2

Synonyms:

CJS; HPE9; PHS2; THP1; THP2

SwissProt:

P10070

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and Human ovarian cancer

IHC Recommend dilution:

25-100