兔抗FKBP1A多克隆抗体

Background:

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.

Applications:

ELISA, IHC

Name of antibody:

FKBP1A

Immunogen:

Fusion protein of human FKBP1A

Full name:

FK506 binding protein 1A

Synonyms:

FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A

SwissProt:

P62942

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

50-300