小鼠抗POU5F1单克隆抗体

Background:

This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Mar 2010].

Applications:

WB, IF

Name of antibody:

POU5F1

Immunogen:

Fusion protein of human POU5F1

Full name:

POU class 5 homeobox 1 (POU5F1), transcript variant 1

Synonyms:

Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4

SwissProt:

Q01860

WB Predicted band size:

39 kDa

WB Positive control:

Hela, SVT2, A549, PC12, MCF-7 cell lysates

WB Recommended dilution:

200-1000