兔抗FOXP2多克隆抗体

Background:

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Applications:

ELISA, IHC

Name of antibody:

FOXP2

Immunogen:

Synthetic peptide of human FOXP2

Full name:

forkhead box P2

Synonyms:

SPCH1; CAGH44; TNRC10

SwissProt:

O15409

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human breast cancer

IHC Recommend dilution:

20-100