小鼠抗SEMA4D单克隆抗体

Background:

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.

Applications:

WB, IHC

Name of antibody:

SEMA4D

Immunogen:

Fusion protein of human SEMA4D

Full name:

semaphorin 4D

Synonyms:

CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G

SwissProt:

Q92854

IHC positive control:

Human kidney tissue

IHC Recommend dilution:

200-500

WB Predicted band size:

96 KD

WB Positive control:

Jurkat cell lysate

WB Recommended dilution:

500-2000