兔抗PDGFB多克隆抗体

Background:

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Applications:

ELISA, IHC

Name of antibody:

PDGFB

Immunogen:

Synthetic peptide of human PDGFB

Full name:

Platelet-derived growth factor beta polypeptide

Synonyms：

SIS, SSV, PDGF2, c-sis

SwissProt:

P01127

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human liver cancer and Human ovarian cancer

IHC Recommend dilution:

50-200