兔抗NOTCH4多克隆抗体

Background:

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Applications:

ELISA, WB, IHC

Name of antibody:

NOTCH4

Immunogen:

Synthetic peptide of human NOTCH4

Full name:

notch 4

Synonyms:

INT3

SwissProt:

Q99466

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and Human liver cancer

IHC Recommend dilution:

50-100

WB Predicted band size:

210 kDa

WB Positive control:

Human left kidney paracancerous tissue lysate

WB Recommended dilution:

800-2000