兔抗RRP8多克隆抗体

Background:

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Applications:

ELISA, WB, IHC

Name of antibody:

RRP8

Immunogen:

Fusion protein of human RRP8

Full name:

ribosomal RNA processing 8

Synonyms:

NML; KIAA0409

SwissProt:

O43159

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and Human breast cancer

IHC Recommend dilution:

50-300

WB Predicted band size:

51 kDa

WB Positive control:

Human cerebella tissue, K562 cell lysates

WB Recommended dilution:

500-2000