兔抗NECTIN4多克隆抗体

Background:

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

Applications:

ELISA, IHC

Name of antibody:

NECTIN4

Immunogen:

Fusion protein of human NECTIN4

Full name:

nectin cell adhesion molecule 4

Synonyms:

LNIR; PRR4; EDSS1; PVRL4; nectin-4

SwissProt:

Q96NY8

IHC positive control:

Human colon cancer and Human liver cancer

IHC Recommend dilution:

50-200