兔抗FLT3多克隆抗体

Background:

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Applications:

ELISA, WB, IHC

Name of antibody:

FLT3

Immunogen:

Fusion protein of human FLT3

Full name:

fms related tyrosine kinase 3

Synonyms:

FLK2; STK1; CD135; FLK-2

SwissProt:

P36888

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

113 kDa

WB Positive control:

231 cell lysate

WB Recommended dilution:

500-2000