兔抗FANCD2多克隆抗体

Background:

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.

Applications:

WB

Name of antibody:

FANCD2

Immunogen:

Fusion protein of human FANCD2

Full name:

Fanconi anemia, complementation group D2

Synonyms：

DKFZp762A223; FA-D2; FA4; FACD; FAD; FAD2; FANCD; FLJ23826

SwissProt:

Q9BXW9

WB Predicted band size:

166 kDa

WB Positive control:

HL60 cells

WB Recommended dilution:

500-2000