兔抗DYNLL1多克隆抗体

Background:

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

Applications:

ELISA, WB, IHC

Name of antibody:

DYNLL1

Immunogen:

Fusion protein of human DYNLL1

Full name:

dynein, light chain, LC8-type 1

Synonyms：

LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1

SwissProt:

P63167

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human prostate cancer and human brain

IHC Recommend dilution:

25-100

WB Predicted band size:

10 kDa

WB Positive control:

Mouse brain tissue

WB Recommended dilution:

1000-5000